Hui Xiang , Zhongqi Wu

Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Bt Research, 2024, Vol. 15, No. 4   doi: 10.5376/bt.2024.15.0018
Received: 08 Jun., 2024    Accepted: 20 Jul., 2024    Published: 09 Aug., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Xiang H., and Wu Z.Q., 2024, Comparative genomics of Bt and related Bacillus species, Bt Research, 15(4): 183-192 (doi: 10.5376/bt.2024.15.0018)

Bacillus thuringiensis (Bt) and related Bacillus species hold significant importance in the fields of biocontrol and biotechnology. This study employs comparative genomics to systematically analyze the genomic features of Bt and related Bacillus species, exploring gene expression, the structure and evolution of toxin gene clusters, and the roles of plasmids and mobile genetic elements. The research also includes a comparison with other Bacillus species, revealing their phylogenetic relationships, conserved and unique genomic regions, and mechanisms of horizontal gene transfer. Additionally, functional genomics studies investigate the expression profiles of specific genes, proteomics and metabolomics characteristics, and their roles in environmental adaptation and co-evolution with hosts. This study aims to provide scientific evidence for the agricultural, medical, and industrial applications of Bt, and addresses regulatory and safety considerations. Through this research, new directions for Bt genomics research are anticipated, and practical applications are suggested.

Bacillus thuringiensis; Comparative genomics; Toxin genes; Functional genomics; Biocontrol