Bing Wang , Qikun Huang

Biotechnology Research Center of Cuixi Academy of Biotechology, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Bt Research, 2024, Vol. 15, No. 3   doi: 10.5376/bt.2024.15.0014
Received: 28 Apr., 2024    Accepted: 20 May, 2024    Published: 12 Jun., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Wang B. and Huang Q.K., 2024, Phylogenetic analysis of Bt strains: insights into genetic relationships and divergence, Bt Research, 15(3): 141-153 (doi: 10.5376/bt.2024.15.0014)

This study reviews the current phylogenetic analysis of Bacillus thuringiensis (Bt) strains, focusing on their genetic relationships and divergence. By analyzing various genetic markers, such as the 16S rRNA gene and multi-locus sequence typing (MLST), we reveal significant genetic diversity and complex evolutionary relationships among Bt strains. Horizontal gene transfer (HGT) and recombination events play crucial roles in the genetic adaptability and diversity of Bt, particularly through the plasmid-mediated transfer of insecticidal toxin genes. The paper further explores the applications of Bt in biopesticide development, highlighting its role in agricultural pest control and environmental management. Utilizing whole-genome sequencing and comparative genomics, we provide detailed insights into novel genes and toxins found in Bt strains. Additionally, the study outlines the potential applications of Bt in medicine, plant growth promotion, and bioremediation. I discuss future research directions, emphasizing the importance of further exploring the evolutionary mechanisms of Bt strains, genetic engineering enhancements, and the long-term impacts of Bt applications in various ecosystems.

Bacillus thuringiensis; Phylogenetic analysis; Genetic diversity; Horizontal gene transfer