Review and Progress

Relationship between HIV Mutation and Host Antibody Response  

Wei Zhang
Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, China
Author    Correspondence author
Molecular Pathogens, 2024, Vol. 15, No. 1   doi: 10.5376/mp.2024.15.0002
Received: 20 Nov., 2023    Accepted: 25 Dec., 2023    Published: 20 Jan., 2024
© 2024 BioPublisher Publishing Platform
This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Zhang W., 2024, Relationship between HIV mutation and host antibody response, Molecular Pathogens, 15(1): 9-16 (doi: 10.5376/mp.2024.15.0002)


The variation of the HIV virus is caused by its high mutability and the accumulation of errors during replication. Mutation leads to the production of different subtypes and variants of the virus, which in turn affects the antibody response of the host immune system. This study reviews the mutual relationship between HIV virus variation and host antibody response. Antibodies, as a major component of the immune system, play a crucial role in the process of infection. This study provides a systematic overview of the mechanisms underlying HIV-1 viral variation and the different types of mutations. It also discusses the mechanisms of host antibody response, the structure and function of antibodies, and the impact of viral variation on antibody recognition and binding, particularly the challenges posed by antibody escape mutations. The study comprehensively analyzes existing research methods and technologies, such as genetic sequencing and monoclonal antibody techniques, and emphasizes their importance in studying HIV-1 viral variation and antibody responses. The study concludes by summarizing the challenges and future directions in research, including strategies for antibody vaccine development, dynamic modeling of virus evolution and antibody responses, and prospects for new therapeutic strategies and drug development.

HIV virus variation; Host antibody response; Mutant strains; Antibody escape; Viral evolution
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