Jiayao Zhou

Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, China
Author    Correspondence author
Molecular Microbiology Research, 2024, Vol. 14, No. 1   doi: 10.5376/mmr.2024.14.0002
Received: 22 Nov., 2023    Accepted: 03 Jan., 2024    Published: 18 Jan., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Zhou J.Y., 2024, Microbiome and chronic diseases: association, causal relationship, and therapeutic potential, Molecular Microbiology Research, 14(1): 10-19 (doi: 10.5376/mmr.2024.14.0002)

The research on the microbiome and chronic diseases is of great significance in understanding the pathogenesis and progression of chronic diseases, developing novel treatment methods, and realizing personalized healthcare. This review introduces the basic concepts and importance of the microbiome, as well as the definition, classification, and global impact of chronic diseases. It delves into the association between the microbiome and various chronic diseases, including cardiovascular diseases, diabetes, obesity, and autoimmune diseases. The review also analyzes the relationship between the composition, function, and metabolites of the microbiome and the development of chronic diseases. It explores the impact of microbiome differences among different populations on chronic diseases, the potential mechanisms by which the microbiome affects the development of chronic diseases, and the interactions between the microbiome and various host systems. It summarizes the applications and potential of the microbiome in the treatment of chronic diseases and provides insights into future research directions and potential breakthroughs. This review aims to reveal the deep connection between the microbiome and chronic diseases, provide new ideas and methods for the prevention and treatment of chronic diseases, and promote the development of personalized healthcare.

Microbiome; Chronic diseases; Association; Causality; Treatment potential