Interaction between Pathogenic Mechanism of Salmonella and Host Immune System
Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, China
Molecular Microbiology Research, 2024, Vol. 14, No. 1 doi: 10.5376/mmr.2024.14.0001
Received: 28 Dec., 2023 Accepted: 29 Dec., 2023 Published: 01 Jan., 2024
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Preferred citation for this article:
Chen C., 2024, Interaction between pathogenic mechanism of Salmonella and host immune system, Molecular Microbiology Research, 14(1): 1-9 (doi: 10.5376/mmr.2024.14.0001)
Salmonella is a bacterium that widely exists in the natural world and can cause various diseases such as gastroenteritis and septicemia. Salmonella invades host cells through its virulence factors, such as serine, endotoxins, and flagella, disrupting the signaling pathways of host cells and evading surveillance and attack by the host immune system. Salmonella can also produce various molecules, such as surface proteins and lipopolysaccharides, to activate the host immune system's inflammatory response, leading to the formation of inflammatory lesions. Furthermore, Salmonella infection can affect both cellular and humoral immunity of the host immune system. Studies have found that Salmonella infection can result in reduced functionality of macrophages and dendritic cells, inhibition of T cell activation and proliferation, thereby weakening the host immune system's resistance. The research also introduces the diagnosis and treatment methods for Salmonella infection, including bacterial culture, molecular biology detection, and antibiotic therapy, and provides prospects for the study of the pathogenic molecular mechanisms of Salmonella and the interaction with the host immune system. Future research needs to further explore the virulence factors and immune evasion mechanisms of Salmonella, investigate the strategies of the host immune system's response, and provide a more scientific basis for the prevention and treatment of Salmonella infection.
Salmonella; Pathogenic mechanism; Immune escape; Host immune system; Prevention and treatment
Molecular Microbiology Research
• Volume 14