Research Article

Interaction between Pathogenic Mechanism of Salmonella and Host Immune System  

Chen Chen
Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, China
Author    Correspondence author
Molecular Microbiology Research, 2024, Vol. 14, No. 1   doi: 10.5376/mmr.2024.14.0001
Received: 11 Nov., 2023    Accepted: 16 Dec., 2023    Published: 01 Jan., 2024
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Chen C., 2024, Interaction between pathogenic mechanism of Salmonella and host immune system, Molecular Microbiology Research, 14(1): 1-9 (doi: 10.5376/mmr.2024.14.0001)

Abstract
Salmonella is a bacterium that widely exists in the natural world and can cause various diseases such as gastroenteritis and septicemia. Salmonella invades host cells through its virulence factors, such as serine, endotoxins, and flagella, disrupting the signaling pathways of host cells and evading surveillance and attack by the host immune system. Salmonella can also produce various molecules, such as surface proteins and lipopolysaccharides, to activate the host immune system's inflammatory response, leading to the formation of inflammatory lesions. Furthermore, Salmonella infection can affect both cellular and humoral immunity of the host immune system. Studies have found that Salmonella infection can result in reduced functionality of macrophages and dendritic cells, inhibition of T cell activation and proliferation, thereby weakening the host immune system's resistance. The research also introduces the diagnosis and treatment methods for Salmonella infection, including bacterial culture, molecular biology detection, and antibiotic therapy, and provides prospects for the study of the pathogenic molecular mechanisms of Salmonella and the interaction with the host immune system. Future research needs to further explore the virulence factors and immune evasion mechanisms of Salmonella, investigate the strategies of the host immune system's response, and provide a more scientific basis for the prevention and treatment of Salmonella infection.
Keywords
Salmonella; Pathogenic mechanism; Immune escape; Host immune system; Prevention and treatment
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