'Viral Relicts' in the Genome could Fuel Neurodegeneration
Published:17 Sep.2023 Source:DZNE - German Center for Neurodegenerative Diseases
Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers at DZNE come to this conclusion on the basis of studies on cell cultures. They report on this in the journal Nature Communications. In their view, such "endogenous retroviruses" could contribute to the spread of aberrant protein aggregates -- hallmarks of certain dementias -- in the brain. Thus, these viral relicts would be potential targets for therapies.
It has been suspected for some time that viral infections contribute to the genesis and development of neurodegenerative diseases. Laboratory studies by DZNE scientists now suggest a mechanism that, although related to viruses, does not require infection by external pathogens. According to this study, the culprits would be "endogenous retroviruses" that are naturally present in the human genome.
"During evolution, genes from numerous viruses have accumulated in our DNA. Most of these gene sequences are mutated and normally muted," explained Ina Vorberg, research group leader at DZNE and a professor at the University of Bonn. "However, there is evidence that endogenous retroviruses are activated under certain conditions and contribute to cancer and neurodegenerative diseases. Indeed, proteins or other gene products derived from such retroviruses are found in the blood or tissue of patients."