Hidden 'Super Spreaders' Spur Dengue Fever Transmission
Published:29 Mar.2023 Source:Emory University
PNAS Nexus published the research led by scientists at Emory University, which drew from six years of data collected in the Amazonian city of Iquitos, Peru.
The results found that 8% of human activity spaces in the study accounted for more than half of infections during a dengue outbreak. And these "super spreader" spaces were associated with a predominance of asymptomatic cases, or 74% of all infections.
"Our findings show that any public health intervention that focuses on responding to symptomatic cases of dengue is going to fail to control an outbreak," says Gonzalo Vazquez-Prokopec, first author of the study and an Emory associate professor of environmental sciences. "Symptomatic cases represent only the tip of the iceberg."
Co-authors of the research include Uriel Kitron, Emory professor of environmental sciences; Lance Waller, professor of biostatistics and bioinformatics at Emory's Rollins School of Public Health; and scientists from University of California-Davis, Tulane University, San Diego State University, University of Notre Dame, North Carolina State University and the U.S. Naval Medical Research Unit in Lima, Peru.
Dengue fever is caused by a virus transmitted by the bite of a female Aedes aegypti mosquito. When the insect takes a blood meal from a human infected with dengue, the virus begins replicating within the mosquito. The virus may then spread to another person that the mosquito bites days later.
This species of mosquito feeds exclusively on human blood, has a limited flight range of about 100 meters and thrives in sprawling urban areas of the tropics and subtropics. Its preferred habitat is inside homes, where it rests on the backs of furniture and at the bases of walls. Even the little bit of water held by an upturned bottle cap can serve as a nursery for its larvae.